Cerebral organoids enter the fold
نویسندگان
چکیده
منابع مشابه
Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain.
Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown. We compared epigenomic and regulatory features in cerebral organoids and human fetal brain, using genome-wide, base resolution DNA methylome and transcripto...
متن کاملCerebral Organoids in a Dish: Progress and Prospects
A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.
متن کاملDerivation of Functional Human Astrocytes from Cerebral Organoids
Astrocytes play a critical role in the development and homeostasis of the central nervous system (CNS). Astrocyte dysfunction results in several neurological and degenerative diseases. However, a major challenge to our understanding of astrocyte physiology and pathology is the restriction of studies to animal models, human post-mortem brain tissues, or samples obtained from invasive surgical pr...
متن کاملCerebral organoids will play an essential role in understanding the development of the brain.
Stem cell studies are being currently widely used in neuroscience particularly for degenerative, developmental, and neoplastic disorders in addition to trauma. Laboratory studies of recurrent glioblastoma multiforme (GBM) stem cell vaccinations have already been completed and a Phase I safety study in human volunteers with recurrent GBM is in progress (1). Findings derived from animal studies w...
متن کاملImmunotherapeutic organoids
Therapeutic monoclonal antibodies have revolutionized the treatment of cancer and other diseases. However, several limitations of antibody-based treatments, such as the cost of therapy and the achievement of sustained plasma levels, should be still addressed for their widespread use as therapeutics. The use of cell and gene transfer methods offers additional benefits by producing a continuous r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Methods
سال: 2017
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.4212